Ganoderma amboinense polysaccharide prevents obesity by regulating gut microbiota in high-fat-diet mice

Obesity has caused serious economic and health problems in the world. Gut microbiota is a complex ecosystem plays an important role preventing obesity. The purpose of this study was to investigate effects Ganoderma amboinense (G. amboinense) polysaccharide (GAP) on obesity-related characteristics high-fat-diet (HFD) mice, determine whether GAP treatment can regulate gut HFD-mice. extracted from G. by hot water extracting with further separation purification. Male C57BL/6 mice were fed HFD supplemented for 8 weeks. results showed that had regulatory effect HFD-mice, abundance 3 genera multiple keys signaling pathways regulated. And effectively prevented weight gain fat accumulation, improved glucose tolerance, reduced serum liver lipid concentrations inflammation